1. 

ADVERSITY

A. Failure
B. Helplessness
C. Misfortune
D. Crisis

Answer: Option C

Explanation:

Meanings of the given words:
Adversity is a very difficult or unfavorable situation.

Adversity :  hard knock, difficult situation, trouble, distress, affliction, calamity..

Failure : non-success , lack of success, non-fulfillment, defeat, abortion

Helplessness : a feeling of being unable to manage.

Misfortune: tough luck, ill luck, bad luck.

Crisis : a crucial stage or turning point.